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The prokaryotic organism is cultured under conditions such that the modified tetracycline repressor is expressed, cost of midamor and in the presence of tetracycline or tetracycline analog at a concentration sufficient to repress expression of the putative essential gene. (time asleep/time in bed) less than 85%, cost of midamor or sleep disturbance more than 3 times a week.
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Additionally, antibiotics often make people so sick they are unwilling to go another round!
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